Coronin-1A Links Cytoskeleton Dynamics to TCRαβ-Induced Cell Signaling
نویسندگان
چکیده
منابع مشابه
Coronin-1A Links Cytoskeleton Dynamics to TCRαβ-Induced Cell Signaling
Actin polymerization plays a critical role in activated T lymphocytes both in regulating T cell receptor (TCR)-induced immunological synapse (IS) formation and signaling. Using gene targeting, we demonstrate that the hematopoietic specific, actin- and Arp2/3 complex-binding protein coronin-1A contributes to both processes. Coronin-1A-deficient mice specifically showed alterations in terminal de...
متن کاملCoronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling
Actin polymerization plays a critical role in activated T lymphocytes both in regulating T cell receptor (TCR)-induced immunological synapse (IS) formation and signaling. Using gene targeting, we demonstrate that the hematopoietic specific, actinand Arp2/3 complex-binding protein coronin-1A contributes to both processes. Coronin-1A-deficient mice specifically showed alterations in terminal deve...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0003467